The unmanned plane fired missiles at a vehicle near the village of Al-Manaseh, in the area of Rada, late on Saturday, the official said.
Among those who died was prominent local militant Saleh Mohammed Al-Ameri, the official said, adding that two other militants were killed and two were wounded.
On Friday, a US drone strike killed two suspected members of Al-Qaeda in the town of Shehr in the eastern province of Hadramawt.
This followed a similar operation last Monday when six other suspected members of Al-Qaeda, including a Jordanian, were killed in separate strikes in Rada and Shehr.
US drones have backed Yemeni forces combating militants of Al-Qaeda in the Arabian Peninsula, the group’s Yemen branch, considered by Washington to be the most active and deadliest franchise of the global jihadist network.
The Washington-based think tank New America Foundation said on Thursday that US drone attacks in Yemen have risen to 53 this year, compared to 18 last year.
